Description

cis-4-Trifluoromethyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected carboxylic acid group and a strategically positioned trifluoromethyl moiety. This compound is critically important for medicinal chemistry research and development, particularly in the synthesis of bioactive molecules where the introduction of fluorine atoms can dramatically enhance metabolic stability, lipophilicity, and binding affinity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex piperidine-based scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to incorporate the beneficial properties of the trifluoromethyl group into drug candidates.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate in the development of robust, scalable synthetic routes for candidate drugs.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, or insecticides where the piperidine and fluorine motifs contribute to biological activity.
• Ligand & Catalyst Development: Potential precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	cis-4-Trifluoromethyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	1993317-42-2
Molecular Formula	C12H18F3NO4
Molecular Weight	297.27 g/mol
Synonyms	1-tert-Butyl 2-carboxy-4-(trifluoromethyl)piperidine-1,2-dicarboxylate; 1-(tert-Butoxycarbonyl)-4-(trifluoromethyl)piperidine-2-carboxylic acid; cis-1-Boc-4-trifluoromethylpipecolic acid; (2S,4S)-1-Boc-4-(trifluoromethyl)piperidine-2-carboxylic acid (stereoisomer); (2R,4R)-1-Boc-4-(trifluoromethyl)piperidine-2-carboxylic acid (stereoisomer); 4-(Trifluoromethyl)pipecolic acid 1-tert-butyl ester; BOC-4-CF3-Pip-OH; Protected 4-CF3-pipecolic acid
EINECS	Contact for details

Quality Control

Our cis-4-Trifluoromethyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (Titration)	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.