Description

n-Boc-Peg3-Benzyl Ester CAS NO 1975173-67-1 is a high-purity, protected polyethylene glycol (PEG) derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a benzyl ester terminus. This compound is a critical building block in the synthesis of complex molecules, offering a versatile linker for the controlled introduction of hydrophilic PEG spacers and subsequent functionalization. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing prodrugs, antibody-drug conjugates (ADCs), and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing prodrugs and modifying active pharmaceutical ingredients (APIs) to enhance solubility and pharmacokinetic properties.
• Bioconjugation Linker: Used in the synthesis of antibody-drug conjugates (ADCs), peptide-drug conjugates, and other biopharmaceuticals to attach payloads via cleavable or stable linkages.
• Polymer Chemistry: Serves as a functional monomer or chain extender in the creation of specialized PEG-based copolymers, hydrogels, and smart materials.
• Protecting Group Strategy: The acid-labile Boc group provides orthogonal protection for amines in multi-step organic synthesis, particularly in peptide and oligonucleotide chemistry.
• Chemical Biology Probes: Employed in the development of labeled compounds and probes for studying biological processes and drug delivery mechanisms.
• Material Surface Functionalization: Used to modify surfaces with PEG brushes to create anti-fouling, non-immunogenic coatings for medical devices and implants.

Basic Information

Product Name	n-Boc-Peg3-Benzyl Ester
CAS No.	1975173-67-1
Molecular Formula	C22H34O8
Molecular Weight	426.5 g/mol
Synonyms	1-Boc-3,6,9-trioxa-12-azatetradecan-14-oic acid benzyl ester; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-[(1,1-dimethylethoxy)carbonyl]-, phenylmethyl ester; Boc-NH-PEG3-CH2CH2-COOBn; tert-Butyl (12-(benzyloxy)-3,6,9-trioxa-12-oxododecyl)carbamate; Boc-AEEA-AEEA-AEEA-OBn; Boc-PEG3-benzyl ester; 3,6,9-Trioxa-12-azatetradecanoic acid, 13-[(1,1-dimethylethoxy)carbonyl]-, phenylmethyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-Peg3-Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring material traceability and reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.