Description

2-Boc-2,6-Diaza-Spiro[3.5]Nonane Hydrochloride is a high-purity, protected spirocyclic diamine building block essential for modern pharmaceutical research and development. Its unique constrained spirocyclic structure makes it a valuable scaffold for creating novel drug candidates with improved metabolic stability and target selectivity. This intermediate is primarily utilized by medicinal chemists and process development scientists in the discovery and synthesis of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of small molecule drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a linker or core component in the design of bifunctional molecules for targeted protein degradation.
• Peptidomimetic Chemistry: Serves as a rigid, non-natural amino acid surrogate to enhance the stability and bioavailability of peptide-based therapeutics.
• Chemical Biology Probes: Employed in the construction of molecular probes for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Acts as a precursor in the development of novel crop protection agents with new modes of action.
• Material Science: Potential monomer for creating specialty polymers with unique thermal and mechanical properties.

Basic Information

Product Name	2-Boc-2,6-Diaza-Spiro[3.5]Nonane Hydrochloride
CAS No.	1965309-45-8
Molecular Formula	C12H21N3O2 • HCl
Molecular Weight	275.77 g/mol (Free base: 239.31 g/mol)
Synonyms	2,6-Diaza-spiro[3.5]nonane-2-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride (1:1); tert-Butyl 2,6-diaza-spiro[3.5]nonane-2-carboxylate hydrochloride; 2-(tert-Butoxycarbonyl)-2,6-diaza-spiro[3.5]nonane hydrochloride; 2-Boc-2,6-diazaspiro[3.5]nonane HCl; Boc-Protected 2,6-Diazaspiro[3.5]nonane HCl; Spirocyclic Diamine Boc-HCl Salt
EINECS	Contact for details

Quality Control

Our 2-Boc-2,6-Diaza-Spiro[3.5]Nonane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.