Description

(S)-1-(4-Chloro-2-(3-Methyl-1H-Pyrazol-1-Yl)Phenyl)-2,2,2-Trifluoroethan-1-Ol is a high-value chiral trifluoromethylated alcohol building block, distinguished by its unique pyrazole-phenyl core structure. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its stereochemistry and fluorine atoms are leveraged to modulate biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Potential building block for specialty polymers and liquid crystals due to its aromatic and fluorinated components.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and probe molecule development.

Basic Information

Product Name	(S)-1-(4-Chloro-2-(3-Methyl-1H-Pyrazol-1-Yl)Phenyl)-2,2,2-Trifluoroethan-1-Ol
CAS No.	1956436-51-3
Molecular Formula	C12H9ClF3N2O
Molecular Weight	289.66 g/mol
Synonyms	(S)-1-[4-Chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethanol; (S)-α-(4-Chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanol; (S)-Trifluoroethanol derivative with chloropyrazolylphenyl; 1-(4-Chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoro-1-(S)-ethanol; CAS 1956436-51-3; (S)-enantiomer of the pyrazole trifluoroethanol intermediate.
EINECS	Contact for details

Quality Control

Our (S)-1-(4-Chloro-2-(3-Methyl-1H-Pyrazol-1-Yl)Phenyl)-2,2,2-Trifluoroethan-1-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.