Description

tert-Butyl n-(5-Oxooxolan-2-Yl)Carbamate CAS NO 1956382-26-5 is a high-purity, protected amino acid derivative featuring a γ-lactam (2-pyrrolidinone) scaffold. This compound serves as a critical chiral building block and versatile synthetic intermediate in advanced organic synthesis. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, neurological agents, and other N-heterocyclic-based therapeutics.
• Peptidomimetics & Constrained Peptide Design: Used to introduce rigid, turn-inducing γ-lactam motifs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Serves as a precursor for chiral amines and amino alcohols after deprotection and further functionalization of the lactam ring.
• Medicinal Chemistry Research: A valuable scaffold for constructing focused libraries in drug discovery programs targeting various enzyme families.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke multi-step synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	tert-Butyl n-(5-Oxooxolan-2-Yl)Carbamate
CAS No.	1956382-26-5
Molecular Formula	C9H15NO4
Molecular Weight	201.22 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]-5-oxotetrahydrofuran; 2-[(tert-Butoxycarbonyl)amino]dihydrofuran-5(2H)-one; 2-(Boc-amino)-γ-butyrolactam; N-Boc-2-amino-γ-butyrolactam; tert-Butyl (5-oxooxolan-2-yl)carbamate; Boc-2-aminodihydro-2H-furan-5-one; (5-Oxooxolan-2-yl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl n-(5-Oxooxolan-2-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and IR spectroscopy. Certificates of Analysis (COA) with full traceability are provided to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.