Description

5-Fluoro-2-Azaspiro[3.3]Heptane Hydrochloride is a high-value, spirocyclic building block and intermediate of significant interest in modern pharmaceutical research and development. Its unique, rigid three-dimensional structure is engineered to improve the potency, selectivity, and metabolic stability of drug candidates. This compound is primarily utilized by medicinal chemists and R&D departments in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key spirocyclic scaffold for the research and synthesis of new chemical entities (NCEs) targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.
• Medicinal Chemistry Building Block: Used to introduce conformational constraint into lead molecules, potentially enhancing binding affinity and reducing off-target effects in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or component in the design of bifunctional molecules for targeted protein degradation.
• Agrochemical Research: Employed as an advanced intermediate in the development of novel crop protection agents with potentially improved efficacy and environmental profiles.
• Chemical Biology Probes: Utilized in the creation of specialized molecular tools for studying enzyme function and biological pathways.

Basic Information

Product Name	5-Fluoro-2-Azaspiro[3.3]Heptane Hydrochloride
CAS No.	1956382-13-0
Molecular Formula	C7H11FN2·HCl
Molecular Weight	178.63 g/mol
Synonyms	5-Fluoro-2-azaspiro[3.3]heptane HCl; 2-Azaspiro[3.3]heptane, 5-fluoro-, hydrochloride; 5-Fluoro-2-azaspiro[3.3]heptane hydrochloride; 5-Fluoro-2-azaspiro[3.3]heptane HCl salt; 5-Fluoro-2-azaspiro[3.3]heptane monohydrochloride; 1956382-13-0; 5-Fluoro-2-azaspiro[3.3]heptane, hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Azaspiro[3.3]Heptane Hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use and can discuss custom synthesis under cGMP guidelines for advanced clinical phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.