Description

1-(4-Fluorophen)-8-n-Boc-1,3,8-Triazaspiro[4.5]Decan-4-On is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and triaza scaffold. This compound is of critical importance for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of innovative small-molecule therapies.

Application

• Key Intermediate in Drug Discovery: Serves as a crucial building block for synthesizing potential pharmacologically active molecules, especially those with spirocyclic architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities (NCEs).
• CNS-Targeted API Synthesis: A vital precursor in the development of active pharmaceutical ingredients (APIs) aimed at neurological and psychiatric conditions.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structural features make it a candidate for incorporation into linker or ligand components of targeted protein degraders.
• Library Synthesis for High-Throughput Screening: Employed to create focused chemical libraries for biological screening against novel targets.
• Process Chemistry & Scale-Up: Used in route scouting and process optimization for the commercial-scale production of investigational drugs.

Basic Information

Item	Details
Product Name	1-(4-Fluorophen)-8-n-Boc-1,3,8-Triazaspiro[4.5]Decan-4-On
CAS No.	1956377-44-8
Molecular Formula	C22H30FN3O3
Molecular Weight	403.49 g/mol
Synonyms	1-(4-Fluorophenyl)-8-(tert-butoxycarbonyl)-1,3,8-triazaspiro[4.5]decan-4-one; tert-Butyl 4-oxo-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decane-8-carboxylate; 8-Boc-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one; 1,3,8-Triazaspiro[4.5]decan-4-one, 1-(4-fluorophenyl)-8-[(1,1-dimethylethoxy)carbonyl]-; BOC-1,3,8-Triazaspiro[4.5]decan-4-one derivative; CAS 1956377-44-8; Spirocyclic triaza intermediate
EINECS	Contact for details

Quality Control

Our production of 1-(4-Fluorophen)-8-n-Boc-1,3,8-Triazaspiro[4.5]Decan-4-On adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Each lot undergoes comprehensive analytical characterization using HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.