Description

4-(Benzyloxy)-6-Ethynylpyridin-2-Ol is a high-purity, advanced pharmaceutical intermediate featuring a unique pyridine core functionalized with both benzyloxy and ethynyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules for drug discovery and development. It is primarily needed by research institutions and pharmaceutical companies engaged in creating novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Organic Synthesis: Utilized in cross-coupling reactions (e.g., Sonogashira) due to its reactive ethynyl group, facilitating the creation of complex molecular architectures.
• Ligand and Catalyst Development: Acts as a precursor for developing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the research and development of new crop protection agents and pesticides.
• Material Science: Investigated as a monomer or precursor for synthesizing specialized polymers and functional organic materials.

Basic Information

Item	Details
Product Name	4-(Benzyloxy)-6-Ethynylpyridin-2-Ol
CAS No.	1956328-37-2
Molecular Formula	C14H11NO2
Molecular Weight	225.24 g/mol
Synonyms	6-Ethynyl-4-(phenylmethoxy)-2-pyridinol; 2-Pyridinol, 6-ethynyl-4-(phenylmethoxy)-; 4-(Benzyloxy)-6-ethynyl-2-hydroxypyridine; 4-(Benzyloxy)-6-ethynylpyridin-2-ol; 6-Ethynyl-4-(benzyloxy)pyridin-2-ol; 4-Benzyloxy-6-ethynyl-2-pyridone (tautomer)
EINECS	Contact for details

Quality Control

Our 4-(Benzyloxy)-6-Ethynylpyridin-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.