Description

5-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel therapeutic agents targeting the central nervous system. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique spirocyclic scaffold.
• Protease Inhibitor Development: Serves as a core structural motif in the research of enzyme inhibitors.
• Ligand Synthesis for Receptor Studies: Employed in creating novel ligands for pharmacological characterization of various receptor subtypes.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	5-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One Hydrochloride
CAS No.	1956318-12-9
Molecular Formula	C12H11Cl2NO2
Molecular Weight	272.13 g/mol
Synonyms	5-Chloro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one hydrochloride; 5-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine]-3-one HCl; 5-Chloro-3-oxo-3H-spiro[isobenzofuran-1,4'-piperidine] hydrochloride; 5-Chlorospiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride; 1956318-12-9; Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one, 5-chloro-, hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Chloro-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.