Description

2-(tert-Butoxycarbonyl)-2-Azaspiro[3.4]Octane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and Boc-protected amine structure. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space due to its constrained spirocyclic scaffold.
• Peptidomimetic Synthesis: Serves as a conformationally restricted amino acid analog in the design and synthesis of peptide mimics to improve metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the development of tool compounds and molecular probes for investigating biological pathways and target validation.
• Process Chemistry Development: Used in scaling up synthetic routes for preclinical and clinical trial material (CTM) production under cGMP guidelines.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening (HTS) in early-stage drug discovery.

Basic Information

Product Name	2-(tert-Butoxycarbonyl)-2-Azaspiro[3.4]Octane-1-Carboxylic Acid
CAS No.	1955492-62-2
Molecular Formula	C₁₃H₂₁NO₄
Molecular Weight	255.31 g/mol
Synonyms	1-Boc-2-azaspiro[3.4]octane-2-carboxylic acid; 2-(Boc)-2-azaspiro[3.4]octane-1-carboxylic acid; 2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.4]octane-1-carboxylic acid; 2-Azaspiro[3.4]octane-1-carboxylic acid, 2-(1,1-dimethylethoxy)carbonyl]-; tert-Butyl 1-carboxy-2-azaspiro[3.4]octane-2-carboxylate; Boc-2-azaspiro[3.4]octane-1-COOH; 1955492-62-2
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonyl)-2-Azaspiro[3.4]Octane-1-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and impurity profiles. We support cGMP-compliant production for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.