Description

Methyl 4-Bromo-2-Fluoro-5-Methylphenylacetate is a high-purity fluorinated and brominated aromatic ester building block essential for advanced organic synthesis. This compound is valued for its dual halogen functionality, which provides versatile reactivity for constructing complex molecular architectures. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and pesticides, leveraging the fluorine and bromine atoms for bioactivity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores used in electronic materials for displays and lighting.
• Cross-Coupling Reactions: The bromoaryl moiety makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating specialized chemical libraries.
• Fine Chemical Production: Utilized in the custom synthesis of complex, high-value specialty chemicals for various technological applications.

Basic Information

Product Name	Methyl 4-Bromo-2-Fluoro-5-Methylphenylacetate
CAS No.	1952356-60-3
Molecular Formula	C10H10BrFO2
Molecular Weight	261.09 g/mol
Synonyms	Methyl (4-bromo-2-fluoro-5-methylphenyl)acetate; 4-Bromo-2-fluoro-5-methylbenzeneacetic acid methyl ester; (4-Bromo-2-fluoro-5-methylphenyl)acetic acid methyl ester; Methyl 2-(4-bromo-2-fluoro-5-methylphenyl)acetate; Methyl 4-bromo-2-fluoro-5-methylbenzeneacetate; Methyl α-(4-bromo-2-fluoro-5-methylphenyl)acetate
EINECS	Contact for details

Quality Control

Our Methyl 4-Bromo-2-Fluoro-5-Methylphenylacetate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥97% (by HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and advanced material supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.