Description

trans-5-Benzyl 1-tert-Butyl 3-Oxotetrahydro-2H-Spiro[Piperidine-4,1-Pyrrolo[3,4-C]Pyrrole]-1,5(3H)-Dicarboxylate is a sophisticated spirocyclic piperidine-pyrrolopyrrole derivative, serving as a critical advanced pharmaceutical intermediate in modern synthetic chemistry. Its complex, rigid molecular framework makes it a valuable building block for constructing novel bioactive compounds, particularly in medicinal chemistry research and development. This high-purity intermediate is essential for pharmaceutical manufacturers and contract research organizations (CROs) focused on developing new therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates, particularly those targeting protein kinases and other enzymes.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Employed in the research and process development stages for new Active Pharmaceutical Ingredients (APIs) with spirocyclic architectures.
• Chemical Biology Probes: Serves as a core structure for developing selective chemical probes to study biological pathways and target validation.
• Custom Synthesis: Utilized by fine chemical suppliers for the custom synthesis of proprietary compounds for client-specific R&D projects.

Basic Information

Product Name	trans-5-Benzyl 1-tert-Butyl 3-Oxotetrahydro-2H-Spiro[Piperidine-4,1-Pyrrolo[3,4-C]Pyrrole]-1,5(3H)-Dicarboxylate
CAS No.	1951442-13-9
Molecular Formula	C24H31N3O5
Molecular Weight	441.52 g/mol
Synonyms	1,5(3H)-Dicarboxylic acid, 3-oxotetrahydro-2H-spiro[piperidine-4,1'-pyrrolo[3,4-c]pyrrole]-, 5-benzyl 1-(1,1-dimethylethyl) ester, trans-; trans-5-Benzyl 1-tert-butyl 3-oxo-1,2,3,5,6,7-hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrrole]-1,5-dicarboxylate; Benzyl tert-butyl spiro(piperidine-4,1'-pyrrolo[3,4-c]pyrrole) dicarboxylate; CAS 1951442-13-9; Spirocyclic piperidine-pyrrolopyrrole intermediate; BOC-protected spirocyclic amine ester.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to ensure structural identity and high chemical purity (typically ≥95% to ≥98%). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development and cGMP-grade production to meet the exacting standards of pharmaceutical R&D and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.