Description

Tos-Peg5-Ch2Cootbu CAS NO 1949793-62-7 is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring a tosyl (Tos) group and a tert-butyl ester (Cootbu) separated by a flexible PEG5 spacer. This compound is engineered as a critical building block for creating stable, water-soluble conjugates and cross-linked materials in advanced research and development. It is primarily utilized by scientists and process developers in the pharmaceutical and bioconjugation sectors who require precise, reliable linkers for drug delivery systems, diagnostic reagents, and biomaterial fabrication.

Application

• Bioconjugation and Linker Chemistry: Acts as a heterobifunctional cross-linker for attaching molecules, peptides, or proteins to surfaces, nanoparticles, or other biomolecules.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key reagent in the synthesis of PEGylated linkers for connecting cytotoxic payloads to monoclonal antibodies.
• Polymer Modification: Used to introduce functional groups (tosyl for further substitution, ester for hydrolysis) into polymer backbones to tailor material properties.
• Prodrug Synthesis: Facilitates the creation of prodrugs where the active pharmaceutical ingredient is temporarily masked by the PEG-ester moiety for controlled release.
• Diagnostic Reagent Formulation: Employed in the development of contrast agents or assay components where solubility and specific reactivity are paramount.
• Material Science Research: Utilized in creating hydrogels or functionalized surfaces for biomedical applications due to its PEG spacer's biocompatibility and functional end-groups.

Basic Information

Item	Details
Product Name	Tos-Peg5-Ch2Cootbu
CAS No.	1949793-62-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-(4-Methylbenzenesulfonyl)-3,6,9,12,15-pentaoxaheptadecan-17-oic acid tert-butyl ester; Tos-PEG5-CH2COOtBu; tert-Butyl 2,5,8,11,14-pentaoxa-17-azanonadecan-19-oate 17-(4-methylbenzenesulfonate); PEG5 Tosylate tert-Butyl Ester; Heterobifunctional PEG Derivative Tos-PEG5-tBu ester; 4-Methylbenzenesulfonic acid 17-(tert-butoxy)-2,5,8,11,14-pentaoxa-17-oxoheptadecyl ester
EINECS	Contact for details

Quality Control

Our Tos-Peg5-Ch2Cootbu is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.