Description

2-(tert-Butoxycarbonyl)-2-Azaspiro[3.4]Octane-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and Boc-protected amine structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules, offering a versatile building block for medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and development, particularly for central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting complex biological pathways.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linkers and warhead components for targeted protein degradation therapeutics.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog to enhance the stability and bioavailability of peptide-based drugs.
• Chemical Biology Research: Employed as a tool compound or scaffold for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.
• Material Science: Can be investigated as a monomer or precursor for specialty polymers with unique structural properties.

Basic Information

Product Name	2-(tert-Butoxycarbonyl)-2-Azaspiro[3.4]Octane-6-Carboxylic Acid
CAS No.	1936652-98-0
Molecular Formula	C₁₃H₂₁NO₄
Molecular Weight	255.31 g/mol
Synonyms	2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.4]octane-6-carboxylic acid; 2-Boc-2-azaspiro[3.4]octane-6-carboxylic acid; 2-(Boc)-2-Azaspiro[3.4]octane-6-carboxylic Acid; 2-Azaspiro[3.4]octane-6-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-; 2-(tert-Butoxycarbonyl)-2-azaspiro[3.4]octane-6-carboxylic acid; Boc-2-Azaspiro[3.4]octane-6-COOH; 1936652-98-0; tert-Butyl 6-carboxy-2-azaspiro[3.4]octane-2-carboxylate
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonyl)-2-Azaspiro[3.4]Octane-6-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot. We support development and commercial projects with material produced under current Good Manufacturing Practice (cGMP) guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.