Description

tert-Butyl 2-Hydroxy-5-Azaspiro[3.4]Octane-5-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel drug candidates. It is primarily sought after by R&D teams and process chemists in the pharmaceutical and biotechnology industries for the synthesis of new therapeutic agents targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) for central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained spirocyclic structure.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Proteolysis Targeting Chimera (PROTAC) Synthesis: Potential use as a component in the linker or ligand design for bifunctional degrader molecules.
• Chemical Biology Probes: Utilized in the development of tool compounds for target validation and pathway analysis in biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 2-Hydroxy-5-Azaspiro[3.4]Octane-5-Carboxylate
CAS No.	1934835-43-4
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	5-Boc-2-Hydroxy-5-Azaspiro[3.4]Octane; 2-Hydroxy-5-azaspiro[3.4]octane-5-carboxylic Acid tert-Butyl Ester; tert-Butyl 2-Hydroxy-5-Azaspiro[3.4]Octane-5-Carboxylate; 5-(tert-Butoxycarbonyl)-5-azaspiro[3.4]octan-2-ol; 1934835-43-4; 5-Azaspiro[3.4]octan-2-ol, 5-(1,1-dimethylethoxy)carbonyl]-; Boc-Protected 2-Hydroxy-5-Azaspiro[3.4]Octane
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Hydroxy-5-Azaspiro[3.4]Octane-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.