Description

Ethyl 3-Aminobicyclo[1.1.1]pentane-1-carboxylate is a high-value, structurally constrained bicyclic building block featuring a rigid [1.1.1]propellane core. This compound is of significant interest for its role in medicinal chemistry and advanced materials science, where its unique three-dimensional geometry and functional groups enable the exploration of novel chemical space. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as fragment-based drug discovery and the synthesis of bioisosteres.

Application

• Pharmaceutical Intermediate: A key synthon for constructing rigid, three-dimensional scaffolds in drug discovery programs, particularly for central nervous system (CNS) and metabolic disease targets.
• Bioisostere Development: Serves as a versatile building block for replacing traditional aromatic or aliphatic rings to improve physicochemical properties like solubility, metabolic stability, and potency.
• Agrochemical Research: Used in the synthesis of novel active ingredients with potentially enhanced activity and environmental profiles.
• Materials Science Precursor: Employed in the development of advanced polymers and functional materials that benefit from its strained, cage-like structure.
• Chemical Biology Probe: Facilitates the creation of tool compounds for studying protein-ligand interactions and biological pathways.
• Academic & Contract Research: Essential for fundamental research in synthetic methodology and the exploration of new chemical entities.

Basic Information

Product Name	Ethyl 3-Aminobicyclo[1.1.1]pentane-1-carboxylate
CAS No.	1934821-79-0
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	Ethyl 3-aminobicyclo[1.1.1]pentane-1-carboxylate; 1-Carbethoxy-3-aminobicyclo[1.1.1]pentane; 3-Amino-BCP-1-carboxylic acid ethyl ester; Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-amino-, ethyl ester; 3-Aminobicyclo[1.1.1]pentane-1-carboxylic Acid Ethyl Ester; 3-Amino-BCP-COOEt; Ethyl 3-Amino-BCP-1-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 3-Aminobicyclo[1.1.1]pentane-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.