Description

tert-Butyl 5-oxo-8-azaspiro[bicyclo[3.2.1]octane-3,2'-morpholine]-8-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and bridged bicyclic architecture. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing novel chemical libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies in drug discovery and development pipelines.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 5-oxo-8-azaspiro[bicyclo[3.2.1]octane-3,2'-morpholine]-8-carboxylate
CAS No.	1934379-72-2
Molecular Formula	C15H23NO4
Molecular Weight	281.35 g/mol
Synonyms	8-[(tert-Butoxy)carbonyl]-5-oxo-8-azaspiro[bicyclo[3.2.1]octane-3,2'-morpholine]; tert-Butyl 5-oxo-8-azaspiro[bicyclo[3.2.1]octane-3,2'-morpholine]-8-carboxylate; 8-Boc-5-oxo-8-azaspiro[bicyclo[3.2.1]octane-3,2'-morpholine]; 1934379-72-2; Azaspiro bicyclo octane carboxylate; Bicyclo[3.2.1]octane-3,2'-morpholine derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-oxo-8-azaspiro[bicyclo[3.2.1]octane-3,2'-morpholine]-8-carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. We support compliance with relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.