Description

tert-Butyl (3R,5R)-3-Amino-5-Fluoropiperidine-1-Carboxylate is a high-purity, chiral piperidine derivative of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise stereochemistry. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and production of complex drug molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• API Development: Used as a building block for constructing the core piperidine scaffold in new chemical entities (NCEs) during preclinical and clinical development phases.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (3R,5R)-configured amino-fluoropiperidine moiety, which is crucial for biological activity and receptor binding.
• Medicinal Chemistry Research: Serves as a valuable starting material for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-up: Utilized in the development and optimization of robust, scalable synthetic routes for commercial pharmaceutical manufacturing.
• Protease Inhibitor Synthesis: A potential intermediate in the synthesis of inhibitors for various enzymes, including proteases, due to its amino and fluoro functional groups.

Basic Information

Product Name	tert-Butyl (3R,5R)-3-Amino-5-Fluoropiperidine-1-Carboxylate
CAS No.	1932247-39-6
Molecular Formula	C10H19FN2O2
Molecular Weight	218.27 g/mol
Synonyms	1-Boc-3-amino-5-fluoropiperidine (3R,5R)-; (3R,5R)-1-(tert-Butoxycarbonyl)-3-amino-5-fluoropiperidine; (3R,5R)-3-Amino-5-fluoropiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl (3R,5R)-3-amino-5-fluoropiperidine-1-carboxylate; (3R,5R)-3-Amino-5-fluoro-1-N-Boc-piperidine; 1-N-Boc-(3R,5R)-3-amino-5-fluoropiperidine; (3R,5R)-5-Fluoro-3-aminopiperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R,5R)-3-Amino-5-Fluoropiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.