Description

1-Pyrrolidinecarboxylic Acid, 3-Amino-2-Methyl-, 1,1-Dimethylethyl Ester, (2R,3R)- is a high-purity, stereochemically defined chiral building block of significant importance in advanced organic synthesis. This compound matters because it provides a critical, enantiomerically pure scaffold for constructing complex molecules with precise three-dimensional architecture. Pharmaceutical R&D and fine chemical manufacturers need this high-value intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring specific stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, including protease inhibitors and other small molecule drugs.
• Peptidomimetic Chemistry: Serves as a constrained proline analog for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Agrochemical Research: Employed in the synthesis of enantiomerically pure agrochemicals, such as herbicides and fungicides, where specific isomer activity is required.
• Ligand and Catalyst Development: Acts as a precursor for nitrogen-containing ligands used in transition metal catalysis.
• Academic and Industrial R&D: A valuable tool for medicinal chemists and researchers exploring new chemical entities and structure-activity relationships.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 3-Amino-2-Methyl-, 1,1-Dimethylethyl Ester, (2R,3R)-
CAS No.	1932000-01-5
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	(2R,3R)-3-Amino-2-methyl-1-(tert-butoxycarbonyl)pyrrolidine; tert-Butyl (2R,3R)-3-amino-2-methylpyrrolidine-1-carboxylate; (2R,3R)-Boc-3-amino-2-methylpyrrolidine; (2R,3R)-1-Boc-3-amino-2-methylpyrrolidine; (2R,3R)-3-Amino-2-methylpyrrolidine-1-carboxylic acid tert-butyl ester; (2R,3R)-3-Amino-N-Boc-2-methylpyrrolidine; (2R,3R)-2-Methyl-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is controlled via modern analytical techniques to guarantee high chiral purity and chemical identity. Certificates of Analysis (COA) detailing specifications such as enantiomeric excess (ee), chemical purity, and residual solvents are available upon request. We adhere to a cGMP-compliant quality management system suitable for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.