Description

Fmoc-α-Me-D-Ser-Lactone is a specialized, non-proteinogenic amino acid derivative used in advanced peptide synthesis. This compound is critical for introducing conformational constraints and enhancing the metabolic stability of therapeutic peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based drugs and bioactive compounds. The product, identified by CAS No. 1926163-89-4, offers high purity and reliability for demanding synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating α-methyl-serine lactone motifs into peptide chains.
• Conformationally Restricted Peptide Design: For creating stabilized peptide secondary structures to improve target binding affinity.
• Pharmaceutical Intermediate: In the research and development of potential peptide therapeutics for metabolic diseases and oncology.
• Biochemical Research: As a tool compound for studying enzyme-substrate interactions and peptide stability.
• Peptidomimetic Development: For designing and synthesizing molecules that mimic the structure and function of natural peptides.
• API (Active Pharmaceutical Ingredient) Synthesis: As a chiral intermediate in the multi-step synthesis of complex active ingredients.

Basic Information

Product Name	Fmoc-α-Me-D-Ser-Lactone
CAS No.	1926163-89-4
Molecular Formula	C20H19NO5
Molecular Weight	353.37 g/mol
Synonyms	Fmoc-α-Me-D-Ser-Lactone; (3R)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4,4-dimethyloxetan-2-one; Fmoc-D-α-methylserine lactone; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-α-methylserine lactone; Fmoc-D-α-MeSer(δ-lactone); Fmoc-A-Me-D-Ser-Lac; Nα-Fmoc-D-α-methylserine δ-lactone; BOC Sciences Brand Name: BBL-BB-01313
EINECS	Contact for details

Quality Control

Our Fmoc-α-Me-D-Ser-Lactone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and chiral analysis to ensure enantiomeric integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications for research and pharmaceutical development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.