Description

Mal-Amido-Peg8-Tfp Ester is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group for thiol conjugation and a tetrafluorophenyl (TFP) ester for amine-reactive coupling. This compound is essential for creating stable, site-specific bioconjugates with high efficiency and minimal cross-reactivity. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, antibody-drug conjugate (ADC) production, and advanced diagnostic reagent formulation.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via thiol and amine groups.
• PEGylation Reagent: Modification of peptides, proteins, and enzymes to enhance solubility, stability, and pharmacokinetic profiles.
• Diagnostic Probe Synthesis: Construction of fluorescent or enzyme-labeled detection probes for immunoassays and imaging.
• Surface Functionalization: Immobilization of biomolecules onto nanoparticles, biosensors, or solid supports for targeted delivery and sensing applications.
• Crosslinking Agent: For creating defined protein-protein or protein-polymer conjugates in structural biology and materials science.
• Biomaterial Modification: Introducing bioactive ligands onto hydrogels and polymer scaffolds for tissue engineering.

Basic Information

Product Name	Mal-Amido-Peg8-Tfp Ester
CAS No.	1924596-31-5
Molecular Formula	C41H55F4N3O15
Molecular Weight	905.9 g/mol
Synonyms	Maleimide-PEG8-TFP Ester; TFP-PEG8-Maleimide; α-Tetrafluorophenyl-ω-maleimide octaethylene glycol; Tetrafluorophenyl ester of 3-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-1-oxo-1-(8-oxo-12,15,18,21,24,27,30,33-octaoxa-11-azapentatriacontyl)pentatriacontane-35-carboxylic acid; 4-(2,3,5,6-Tetrafluorophenoxy)-4-oxobutyl-PEG8-maleimide; Heterobifunctional PEG linker, Mal-PEG8-TFP; Amine and Thiol Reactive PEG Crosslinker
EINECS	Contact for details

Quality Control

Our Mal-Amido-Peg8-Tfp Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.