Description

(3S,5R)-3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, stereochemically defined piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its primary importance lies in providing a protected amino-hydroxy piperidine scaffold, which is essential for constructing complex molecules with precise three-dimensional architecture. This compound is particularly vital for pharmaceutical R&D and production, where it is used in the development of active pharmaceutical ingredients (APIs), especially for neurological and metabolic disorders, as well as in the synthesis of sophisticated agrochemicals and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• API (Active Pharmaceutical Ingredient) Development: Used in constructing the core piperidine moiety of various APIs, leveraging its defined (3S,5R) stereochemistry.
• Agrochemical Synthesis: Serves as a building block for creating advanced, stereoselective pesticides and herbicides.
• Asymmetric Catalysis Ligand Precursor: Potential use in the development of chiral ligands for asymmetric hydrogenation and other catalytic processes.
• Peptidomimetics & Bioconjugation: The protected amino and hydroxy groups make it suitable for constructing peptide analogs and bioconjugation linkers.
• Academic & Industrial Research: A valuable reagent for medicinal chemistry programs and process chemistry optimization in both academic and corporate R&D settings.

Basic Information

Product Name	(3S,5R)-3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1923165-22-3
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	tert-Butyl (3S,5R)-3-amino-5-hydroxypiperidine-1-carboxylate; (3S,5R)-3-Amino-5-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-amino-5-hydroxypiperidine (stereo-defined); (3S,5R)-1-N-Boc-3-amino-5-hydroxypiperidine; (3S,5R)-3-Amino-5-piperidinol, 1-(1,1-dimethylethyl) ester; Boc-3-amino-5-hydroxypiperidine (3S,5R)-isomer; Chiral Boc-protected aminohydroxypiperidine
EINECS	Contact for details

Quality Control

Our (3S,5R)-3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. We provide comprehensive analytical data including HPLC/GC purity, chiral purity, and identity confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting compliance with agreed specifications. Our quality commitment aligns with cGMP and ICH Q7 guidelines where applicable, ensuring traceability and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.