Description

5-Bromo-2H-Spiro[Benzofuran-3,4'-Piperidine] Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of new therapeutic agents. The salt form enhances stability and handling properties for precise synthetic applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug molecules, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• CNS Drug Development: Serves as a core structural motif for developing ligands targeting receptors like serotonin or dopamine receptors.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for studying novel organic synthesis methodologies and heterocyclic chemistry.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	5-Bromo-2H-Spiro[Benzofuran-3,4'-Piperidine] Hydrochloride
CAS No.	1923052-18-9
Molecular Formula	C13H15BrClNO
Molecular Weight	316.62 g/mol
Synonyms	5-Bromo-2H-spiro[benzofuran-3,4'-piperidine] hydrochloride; 5-Bromo-2H-spiro[1-benzofuran-3,4'-piperidine] HCl; 5-Bromospiro[benzofuran-3,4'-piperidine] hydrochloride; 1923052-18-9; 5-Br-Spiro[benzofuran-3,4'-piperidine] HCl; 5-Bromo-2'H-spiro[benzofuran-3,4'-piperidine] hydrochloride; Spiro[benzofuran-3(2H),4'-piperidine], 5-bromo-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 5-Bromo-2H-Spiro[Benzofuran-3,4'-Piperidine] Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and analytical methods (e.g., HPLC, NMR) is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.