Description

m-Peg4-(Ch2)3-Methyl Ester is a high-purity polyethylene glycol (PEG)-based linker and bifunctional reagent featuring a terminal methyl ester. This compound is engineered to provide a versatile and reactive handle for conjugation chemistry, enabling the precise modification of biomolecules and materials. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require reliable, well-defined chemical spacers for drug delivery systems, diagnostic probes, and polymer synthesis.

Application

• Bioconjugation and ADC Development: Serves as a critical heterobifunctional crosslinker for attaching cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides in the synthesis of antibody-drug conjugates (ADCs) and other biotherapeutics.
• PEGylation Reagent: Used to introduce hydrophilic PEG chains onto drug molecules, peptides, or surfaces to enhance solubility, improve pharmacokinetics, and reduce immunogenicity.
• Polymer and Dendrimer Synthesis: Acts as a building block or initiator in controlled polymerization reactions and the stepwise construction of functionalized dendrimers and star-shaped polymers.
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, and solid supports with reactive ester groups for subsequent coupling with amines, creating functionalized platforms for assays and diagnostics.
• Prodrug Synthesis: Utilized to create cleavable linkages in prodrug designs, where the ester bond can be hydrolyzed under specific physiological conditions to release the active pharmaceutical ingredient.
• Material Science: Incorporated into hydrogels and smart materials to impart specific chemical reactivity, biodegradability, or responsive properties.

Basic Information

Product Name	m-Peg4-(Ch2)3-Methyl Ester
CAS No.	1920109-55-2
Molecular Formula	C16H32O8
Molecular Weight	352.42 g/mol
Synonyms	m-PEG4-(CH2)3-COOCH3; 3,6,9,12-Tetraoxapentadecan-15-oic acid, 15-methyl ester; Methyl 3,6,9,12-tetraoxapentadecanoate; Methyl-PEG4-propionate; mPEG4-CH2CH2CH2-COOMe; Amine-PEG4-acid methyl ester (related); PEG-based C3 spacer methyl ester; Tetraethylene glycol monomethyl ether propionate methyl ester
EINECS	Contact for details

Quality Control

Every batch of m-Peg4-(Ch2)3-Methyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry analysis. Our quality commitment supports applications requiring high standards, including GMP-compatible manufacturing for preclinical and clinical-stage development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen), please contact us.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.