Description

Aminooxy-Peg5-Azide is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an aminooxy group and an azide terminus. This compound is engineered for high-efficiency, site-specific bioconjugation, particularly in the development of advanced biologics and diagnostic reagents. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and materials science who require precise and stable linkages between biomolecules and surfaces or other functional groups.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to antibodies via oxime ligation with ketone/aldehyde-modified proteins.
• PEGylation Reagent: Introduction of a hydrophilic PEG spacer to peptides, proteins, or small molecules to improve solubility, stability, and pharmacokinetics.
• Surface Functionalization: Immobilization of biomolecules onto azide-reactive surfaces (via copper-free click chemistry with DBCO or cyclooctyne derivatives) for biosensor and microarray fabrication.
• Biomaterial Crosslinking: Creating hydrogels or functional polymer networks through orthogonal click chemistry reactions.
• Diagnostic Probe Synthesis: Construction of imaging probes and contrast agents by conjugating targeting ligands to reporter molecules.
• Protein/Peptide Labeling: Selective modification of N-termini or glycoproteins for structural and functional studies.

Basic Information

Product Name	Aminooxy-Peg5-Azide
CAS No.	1919045-02-5
Molecular Formula	C21H41N5O8
Molecular Weight	491.59 g/mol
Synonyms	Azido-PEG5-aminooxy; Aminooxy-PEG5-N3; 2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl O-(2-Aminoethyl)hydroxylamine; 19-Azido-4,7,10,13,16-pentaoxa-2-nonadecanamine, N-hydroxy-; Heterobifunctional PEG Crosslinker, Aminooxy-Azide; O-(2-Aminoethyl)hydroxylamine-PEG5-azide; Aminooxy-PEG5-N3
EINECS	Contact for details

Quality Control

Our Aminooxy-Peg5-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by NMR)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.