Description

Spiro[Isochroman-1,4'-Piperidine] 2,2,2-Trifluoroacetate is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure. This compound is of significant value in modern organic synthesis, particularly for constructing complex molecular architectures required in drug discovery and development. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential therapeutic agents targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its spirocyclic scaffold.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and protein interactions.
• Custom Synthesis: Employed in contract research and manufacturing (CRO/CMO) for the custom production of specialized compounds.
• Library Synthesis: A valuable reactant for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Spiro[Isochroman-1,4'-Piperidine] 2,2,2-Trifluoroacetate
CAS No.	1914148-51-8
Molecular Formula	C16H18F3NO3
Molecular Weight	329.32 g/mol
Synonyms	1',2',3',4'-Tetrahydrospiro[isochromene-1,4'-piperidine] 2,2,2-trifluoroacetate; Spiro[isochroman-1,4'-piperidine] TFA salt; 1,2,3,4-Tetrahydrospiro[isochromene-1,4'-piperidine] trifluoroacetate; 4'-Aza-1,2,3,4-tetrahydrospiro[isochromene-1,4'-piperidine] trifluoroacetate; Spiro[1H-isochromene-1,4'-piperidine] trifluoroacetic acid salt; 1914148-51-8; TFA salt of Spiro[isochroman-1,4'-piperidine].
EINECS	Contact for details

Quality Control

Our Spiro[Isochroman-1,4'-Piperidine] 2,2,2-Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.