Description

Danicopan CAS NO 1903768-17-1 is a potent and selective small molecule inhibitor of factor D, a key serine protease in the alternative complement pathway. This compound is of significant interest for its therapeutic potential in treating complement-mediated diseases. It is primarily utilized by pharmaceutical research organizations and manufacturers engaged in the development of novel treatments for paroxysmal nocturnal hemoglobinuria (PNH) and other complement-driven disorders.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active pharmaceutical ingredient in the formulation of complement inhibitor drugs.
• Clinical Research & Development: Used as a reference standard and investigational compound in preclinical and clinical studies targeting the alternative complement pathway.
• Biochemical Research: Employed as a selective tool compound in in vitro and ex vivo studies to elucidate the role of factor D and the alternative pathway in immune and inflammatory responses.
• Drug Discovery: Acts as a key intermediate or lead compound for the synthesis and development of next-generation complement inhibitors.
• Therapeutic Areas: Targeted for conditions such as Paroxysmal Nocturnal Hemoglobinuria (PNH), atypical Hemolytic Uremic Syndrome (aHUS), C3 Glomerulopathy (C3G), and other complement-mediated diseases.

Basic Information

Product Name	Danicopan
CAS No.	1903768-17-1
Molecular Formula	C23H23N5O4S
Molecular Weight	465.52 g/mol
Synonyms	ALXN2040; ACH-4471; Danicopan hemihydrate; 3-((2S,3R)-3-Ethyl-2-(4-(methylsulfonyl)phenyl)-1,2,3,4-tetrahydroquinolin-6-yl)propanoic acid; 3-[(2S,3R)-3-Ethyl-2-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-quinolin-6-yl]propanoic acid; Factor D Inhibitor ACH-4471
EINECS	Contact for details

Quality Control

Our Danicopan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets high-purity pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.