Description

(E)-Methyl3-(5-Fluoropyridin-3-Yl)Acrylate (Wxfc0787) is a high-purity fluorinated pyridine derivative and a key building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures. The CAS number for this compound is 1902966-90-8.

Application

This fluorinated acrylate ester is a critical synthon for medicinal chemistry and material science research. Its primary applications include:

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the bioactivity of the fluoropyridine moiety.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Utilized in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to introduce the (E)-acryloyl fragment.
• Polymer Modification: Incorporated as a functional monomer to impart specific properties like fluorescence or altered solubility to polymeric materials.
• Chemical Biology Probes: Employed in the design and synthesis of fluorescent tags and molecular probes for biological imaging and assay development.

Basic Information

Product Name	(E)-Methyl3-(5-Fluoropyridin-3-Yl)Acrylate (Wxfc0787)
CAS No.	1902966-90-8
Molecular Formula	C9H8FNO2
Molecular Weight	181.16 g/mol
Synonyms	Methyl (2E)-3-(5-Fluoro-3-pyridinyl)-2-propenoate; (E)-Methyl 3-(5-Fluoropyridin-3-yl)acrylate; trans-Methyl 3-(5-Fluoropyridin-3-yl)acrylate; 3-Pyridineacrylic acid, 5-fluoro-, methyl ester, (2E)-; WX-FC0787; 5-Fluoro-3-pyridylacrylic acid methyl ester; Methyl (E)-3-(5-fluoropyridin-3-yl)prop-2-enoate
EINECS	Contact for details

Quality Control

Our (E)-Methyl3-(5-Fluoropyridin-3-Yl)Acrylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most sensitive R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and should be kept away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.