Description

m-Peg3-Sulfone-Peg3-Azide is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a sulfone and an azide group, designed for advanced bioconjugation and click chemistry applications. This compound is critical for creating stable, site-specific linkages in the development of complex biomolecules and materials. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications ranging from antibody-drug conjugate (ADC) development to hydrogel fabrication.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key building block for constructing cleavable or non-cleavable linkers between cytotoxic payloads and monoclonal antibodies.
• Bioconjugation & Protein Modification: Enables site-specific labeling and functionalization of proteins, peptides, and other biomolecules via copper-free or copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Polymer & Materials Science: Used as a crosslinking agent or functional monomer in the synthesis of smart hydrogels, drug delivery systems, and surface coatings.
• Diagnostic Reagent Development: Facilitates the attachment of detection probes (e.g., fluorophores, enzymes) to targeting molecules for immunoassays and biosensors.
• Peptide & Oligonucleotide Synthesis: Acts as a spacer or linker to introduce solubility, stability, and specific reactive handles during solid-phase synthesis.
• Chemical Biology Probes: Essential for creating activity-based probes and affinity tags to study protein function and interactions in living systems.

Basic Information

Product Name	m-Peg3-Sulfone-Peg3-Azide
CAS No.	1895922-76-5
Molecular Formula	C16H31N3O9S
Molecular Weight	441.5 g/mol
Synonyms	m-PEG3-sulfone-PEG3-azide; Azido-PEG3-sulfone-PEG3-methyl; Methyl-PEG3-sulfone-PEG3-azide; 1-Azido-3,6,9,12,15-pentaoxa-18-thiaoctadecan-18-one 17,17-dioxide; Heterobifunctional PEG crosslinker, sulfone-azide; Sulfone-PEG3-Azide; PEG-based sulfonyl azide linker
EINECS	Contact for details

Quality Control

Every batch of m-Peg3-Sulfone-Peg3-Azide is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and moisture content. Our quality commitment aligns with the standards required for research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below under desiccant for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.