Description

tert-Butyl 7-Oxo-4-Azaspiro[2.5]Octane-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and lactam structure. This compound is of significant value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological and metabolic disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing spirocyclic compound libraries in hit-to-lead and lead optimization campaigns.
• Protease Inhibitor Development: Used in the research and synthesis of potential inhibitors where the 7-oxo-4-azaspiro[2.5]octane moiety is a key pharmacophore.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of specified APIs for clinical trials.
• Academic Research: Utilized in university and institutional labs for studying novel organic reactions and the properties of strained spirocyclic systems.

Basic Information

Product Name	tert-Butyl 7-Oxo-4-Azaspiro[2.5]Octane-4-Carboxylate
CAS No.	1892578-21-0
Molecular Formula	C12H19NO3
Molecular Weight	225.28 g/mol
Synonyms	4-[(1,1-Dimethylethoxy)carbonyl]-7-oxo-4-azaspiro[2.5]octane; 7-Oxo-4-azaspiro[2.5]octane-4-carboxylic acid tert-butyl ester; tert-Butyl 7-oxo-4-azaspiro[2.5]octane-4-carboxylate; 4-Boc-7-oxo-4-azaspiro[2.5]octane; Boc-4-azaspiro[2.5]octan-7-one-4-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Oxo-4-Azaspiro[2.5]Octane-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.