Description

1,8-Diaza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester Hydrochloride is a high-purity, protected spirocyclic amine building block essential for advanced organic synthesis. This compound is a critical intermediate for medicinal chemistry research, enabling the construction of complex molecular architectures with potential pharmacological activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel active pharmaceutical ingredients (APIs) and chemical probes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for designing peptide analogs and mimetics with improved metabolic stability.
• Chemical Library Production: Employed in combinatorial chemistry and high-throughput screening to generate diverse compound libraries for biological evaluation.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Academic Research: Utilized in university and institutional labs for methodological development and studying spirocyclic compound properties.

Basic Information

Product Name	1,8-Diaza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester Hydrochloride
CAS No.	1890715-57-7
Molecular Formula	C13H25ClN2O2
Molecular Weight	276.80 g/mol
Synonyms	tert-Butyl 1,8-diaza-spiro[4.5]decane-8-carboxylate hydrochloride; 8-(tert-Butoxycarbonyl)-1,8-diaza-spiro[4.5]decane hydrochloride; 1,8-Diazaspiro[4.5]decane-8-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride; Boc-1,8-Diaza-spiro[4.5]decane HCl; 1,8-Diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester HCl; 1,8-Diazaspiro[4.5]decane-8-carboxylate hydrochloride; 1,1-Dimethylethyl 1,8-diazaspiro[4.5]decane-8-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our 1,8-Diaza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided to guarantee the material meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.