Description

Phenyl 2-Bromo-2,2-Difluoroacetate is a high-purity, specialized organic building block featuring a reactive bromodifluoroacetate ester group. This compound is valued for its role as a versatile synthon in the synthesis of complex fluorinated molecules, which are critical in advanced material and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for introducing difluoroacetate motifs and constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing difluoromethylene (CF2) groups, which can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides where the difluoroacetate moiety contributes to biological activity.
• Material Science Research: Serves as a precursor for fluorinated monomers or polymers, contributing to the development of materials with unique surface properties, chemical resistance, or optical characteristics.
• Cross-Coupling Reactions: Acts as an electrophilic reagent in palladium-catalyzed cross-coupling reactions, such as Suzuki or Stille couplings, for carbon-carbon bond formation.
• Fluorine Chemistry Exploration: An essential reagent in methodological studies for new fluorination techniques and the construction of complex fluoroorganic compounds.
• Ligand and Catalyst Development: Used to synthesize fluorinated ligands or catalyst components for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	Phenyl 2-Bromo-2,2-Difluoroacetate
CAS No.	1884337-37-4
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	2-Bromo-2,2-difluoroacetic acid phenyl ester; Phenol, 2-bromo-2,2-difluoroacetate; Bromodifluoroacetic acid phenyl ester; Phenyl bromodifluoroacetate; Difluorobromoacetic acid phenyl ester; Benzyl bromodifluoroacetate (common misnomer); (Bromodifluoroacetyl)oxybenzene
EINECS	Contact for details

Quality Control

Every batch of Phenyl 2-Bromo-2,2-Difluoroacetate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents. The container must be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.