Description

Methyl 4-Bromo-5-Fluoro-2-Iodobenzoate CAS NO 1864354-56-2 is a high-purity, multi-halogenated benzoate ester derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in providing a versatile, functionalized aromatic scaffold for constructing complex molecules, particularly in pharmaceutical discovery and materials science. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise building blocks for cross-coupling reactions and structure-activity relationship studies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in developing novel small-molecule drugs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Sonogashira couplings due to the presence of bromo and iodo substituents, enabling rapid diversification of chemical libraries.
• Chemical Research & Development: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and creating complex molecular architectures.
• Ligand and Catalyst Development: Used to synthesize novel chelating ligands or organocatalysts for asymmetric synthesis and metal-catalyzed transformations.

Basic Information

Product Name	Methyl 4-Bromo-5-Fluoro-2-Iodobenzoate
CAS No.	1864354-56-2
Molecular Formula	C8H5BrFIO2
Molecular Weight	358.93 g/mol
Synonyms	4-Bromo-5-fluoro-2-iodobenzoic acid methyl ester; Methyl 4-bromo-5-fluoro-2-iodobenzoate; Benzoic acid, 4-bromo-5-fluoro-2-iodo-, methyl ester; 2-Iodo-4-bromo-5-fluorobenzoic acid methyl ester; Methyl 2-iodo-4-bromo-5-fluorobenzoate; 4-Bromo-5-fluoro-2-iodo-benzoic acid methyl ester; 1864354-56-2; MFCD31812862
EINECS	Contact for details

Quality Control

Our Methyl 4-Bromo-5-Fluoro-2-Iodobenzoate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.