Description

3-Acetamido-2-Nitrophenyl 4-(Benzyl(Methyl)Amino)-3,5-Difluorobenzoate is a high-purity, advanced pharmaceutical intermediate designed for complex synthesis pathways. This compound is critical for research and development in medicinal chemistry, particularly in the creation of novel active pharmaceutical ingredients (APIs) with targeted biological activity. It serves the needs of pharmaceutical manufacturers, biotechnology R&D labs, and fine chemical synthesis specialists working on next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex, fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Protease Inhibitor Development: Potential precursor in the development of enzyme inhibitors due to its specific benzyl(methyl)amino and difluoro motifs.
• Fluorinated Compound Synthesis: Serves as a versatile intermediate for introducing fluorine atoms and complex aromatic systems into target molecules.
• Chemical Biology Probes: Can be utilized in the creation of labeled probes for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions for clinical trials.

Basic Information

Product Name	3-Acetamido-2-Nitrophenyl 4-(Benzyl(Methyl)Amino)-3,5-Difluorobenzoate
CAS No.	1864061-72-2
Molecular Formula	C23H19F2N3O5
Molecular Weight	455.41 g/mol
Synonyms	4-(Benzyl(methyl)amino)-3,5-difluorobenzoic acid 2-acetamido-6-nitrophenyl ester; 2-Acetamido-6-nitrophenyl 4-[benzyl(methyl)amino]-3,5-difluorobenzoate; 3',5'-Difluoro-4'-[N-benzyl-N-methylamino]-2-acetamido-2'-nitrodiphenyl ether; Benzoic acid, 4-(benzylmethylamino)-3,5-difluoro-, 2-(acetylamino)-6-nitrophenyl ester; 1864061-72-2; 3-Acetamido-2-nitrophenyl 4-(benzylmethylamino)-3,5-difluorobenzoate
EINECS	Contact for details

Quality Control

Our 3-Acetamido-2-Nitrophenyl 4-(Benzyl(Methyl)Amino)-3,5-Difluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.