Description

1-tert-Butyl 3-Methyl 5,5-Difluoro-4-Hydroxypiperidine-1,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated piperidine scaffold. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new drug candidates, particularly in areas requiring fluorinated heterocycles to modulate pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Building Block: Used to introduce the 5,5-difluoro-4-hydroxypiperidine moiety into lead compounds to enhance metabolic stability, bioavailability, and binding affinity.
• Protease Inhibitor Synthesis: Serves as a precursor in the construction of complex molecules designed to inhibit specific proteases, a common target class in antiviral and anticancer therapies.
• Fluorine Chemistry Research: An important compound for academic and industrial research exploring the effects of gem-difluorination on the conformational and electronic properties of piperidine rings.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns for clinical trial materials.
• Library Synthesis for High-Throughput Screening: Employed to create focused chemical libraries for drug discovery screening against novel biological targets.

Basic Information

Product Name	1-tert-Butyl 3-Methyl 5,5-Difluoro-4-Hydroxypiperidine-1,3-Dicarboxylate
CAS No.	1864014-88-9
Molecular Formula	C12H19F2NO5
Molecular Weight	295.28 g/mol
Synonyms	1-tert-Butyl 3-methyl 5,5-difluoro-4-hydroxypiperidine-1,3-dicarboxylate; 5,5-Difluoro-4-hydroxypiperidine-1,3-dicarboxylic acid 1-tert-butyl 3-methyl ester; tert-Butyl methyl 5,5-difluoro-4-hydroxypiperidine-1,3-dicarboxylate; 1-(tert-Butoxycarbonyl)-3-(methoxycarbonyl)-5,5-difluoro-4-hydroxypiperidine; 5,5-Difluoro-4-hydroxy-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-methyl ester; 1864014-88-9; Boc-5,5-difluoro-4-hydroxy-piperidine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 1-tert-Butyl 3-Methyl 5,5-Difluoro-4-Hydroxypiperidine-1,3-Dicarboxylate adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing results from HPLC, NMR, and MS are provided, confirming compliance with agreed specifications. Our quality system supports development under cGMP guidelines where required for advanced clinical stage intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H NMR, ¹³C NMR, ¹⁹F NMR)
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.