Description

2-Aza-Bicyclo[2.2.1]Heptane-2,6-Dicarboxylic Acid 2-tert-Butyl Ester is a high-value, bicyclic amino acid derivative serving as a critical chiral building block and intermediate in advanced organic synthesis. Its constrained, rigid structure is essential for constructing complex molecular architectures with precise stereochemistry, which is paramount in modern pharmaceutical development. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, stereochemically-defined pesticides and herbicides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: The constrained bicyclic framework is utilized to mimic peptide secondary structures, aiding in the development of metabolically stable bioactive molecules.
• Chemical Biology Probes: Employed in the synthesis of specialized probes for studying enzyme mechanisms and biological pathways.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and process development for scale-up.

Basic Information

Product Name	2-Aza-Bicyclo[2.2.1]Heptane-2,6-Dicarboxylic Acid 2-tert-Butyl Ester
CAS No.	1860028-20-1
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-6-carboxylic Acid; 2-Aza-bicyclo[2.2.1]heptane-2,6-dicarboxylic acid 2-tert-butyl ester; 2-Boc-2-azabicyclo[2.2.1]heptane-6-carboxylic Acid; (1R,4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-6-carboxylic Acid; (1S,4R)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-6-carboxylic Acid; 2-Azanorbornane-2,6-dicarboxylic Acid 2-tert-Butyl Ester; Bicyclic Proline Derivative; 2-Azabicyclo[2.2.1]heptane-2,6-dicarboxylic Acid Mono-tert-butyl Ester
EINECS	Contact for details

Quality Control

Our production of 2-Aza-Bicyclo[2.2.1]Heptane-2,6-Dicarboxylic Acid 2-tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.