Description

Methyl 2,3,5-Trifluoro-4-Morpholin-4-Ylbenzoate is a high-value fluorinated aromatic building block featuring a benzoate ester core substituted with a morpholine ring and multiple fluorine atoms. This compound matters as a critical intermediate in modern pharmaceutical and agrochemical research, enabling the synthesis of complex molecules with enhanced biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms and morpholine group contribute to efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Chemical Biology Probes: Employed in the design of fluorinated probes and tags for studying biological mechanisms and target engagement.
• Cross-Coupling Reactions: The aromatic trifluoro and ester groups make it a suitable substrate for palladium-catalyzed cross-coupling reactions to create diverse chemical libraries.
• Fluorine Chemistry Studies: A valuable compound for methodological development in selective fluorination and functional group transformations.

Basic Information

Product Name	Methyl 2,3,5-Trifluoro-4-Morpholin-4-Ylbenzoate
CAS No.	1858250-71-1
Molecular Formula	C12H11F3NO3
Molecular Weight	274.22 g/mol
Synonyms	Methyl 2,3,5-trifluoro-4-morpholinobenzoate; 4-Morpholinecarboxylic acid, 2,3,5-trifluoro-, methyl ester; Benzoic acid, 2,3,5-trifluoro-4-morpholino-, methyl ester; 2,3,5-Trifluoro-4-morpholinobenzoic acid methyl ester; Methyl 2,3,5-trifluoro-4-(morpholin-4-yl)benzoate; 1858250-71-1; MFCD32815506
EINECS	Contact for details

Quality Control

Our Methyl 2,3,5-Trifluoro-4-Morpholin-4-Ylbenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.