Description

4-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]-1,3-Thiazol-2-Amine is a high-value, fluorinated heterocyclic building block designed for advanced synthetic chemistry. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethylpyridine and aminothiazole motifs confer desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorine-containing scaffolds into their molecular targets.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazole and fluorinated pyridine rings.
• Material Science Precursor: Serves as a specialty monomer or ligand in the synthesis of advanced polymers, coatings, or metal-organic frameworks (MOFs).
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a molecular probe in biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	4-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]-1,3-Thiazol-2-Amine
CAS No.	1858241-52-7
Molecular Formula	C10H8F3N3S
Molecular Weight	259.25 g/mol
Synonyms	2-Amino-4-[2-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-thiazole; 4-(2-Methyl-6-(trifluoromethyl)pyridin-3-yl)thiazol-2-amine; 2-Amino-4-(2-methyl-6-(trifluoromethyl)pyridin-3-yl)thiazole; 1858241-52-7; 4-(2-Methyl-6-(trifluoromethyl)-3-pyridinyl)-2-thiazolamine; 3-Thiazolamine, 4-[2-methyl-6-(trifluoromethyl)-3-pyridinyl]-
EINECS	Contact for details

Quality Control

Our 4-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]-1,3-Thiazol-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride/strong alkali conditions; ensure storage areas are free from such incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.