Description

3-Thiophenecarboxylic Acid, 2-Bromo-4-(Trifluoromethyl)-, Methyl Ester is a high-purity, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is valued for its unique molecular architecture, combining a brominated thiophene core with a trifluoromethyl group and a methyl ester, making it an essential intermediate for creating complex molecules with tailored properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications requiring precise structural modification and functional group introduction.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, where the thiophene and trifluoromethyl motifs contribute to biological activity and environmental stability.
• Organic Electronic Materials: Acts as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis, facilitating challenging cross-coupling and functionalization reactions.
• Fluorinated Compound Research: A valuable starting material for introducing the trifluoromethyl group into more complex molecular systems, a common strategy in medicinal chemistry to modulate lipophilicity and metabolic stability.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity, scalable intermediates.

Basic Information

Product Name	3-Thiophenecarboxylic Acid, 2-Bromo-4-(Trifluoromethyl)-, Methyl Ester
CAS No.	1853236-69-7
Molecular Formula	C7H4BrF3O2S
Molecular Weight	289.07 g/mol
Synonyms	Methyl 2-Bromo-4-(trifluoromethyl)thiophene-3-carboxylate; 2-Bromo-4-(trifluoromethyl)thiophene-3-carboxylic Acid Methyl Ester; Methyl 2-Bromo-4-(trifluoromethyl)-3-thiophenecarboxylate; 3-Thiophenecarboxylic acid, 2-bromo-4-(trifluoromethyl)-, methyl ester; 2-Bromo-4-trifluoromethyl-thiophene-3-carboxylic acid methyl ester; 1853236-69-7; MFCD32815511
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Bromo-4-(trifluoromethyl)thiophene-3-carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We operate in compliance with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.