Description

Methyl (2R,3S)-3-Hydroxypyrrolidine-2-Carboxylate Hydrochloride is a high-purity chiral building block essential for the synthesis of complex pharmaceutical intermediates. This compound is valued for its defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) with specific biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Serves as a precursor for constructing complex, stereochemically defined molecules in medicinal chemistry and process development.
• Peptidomimetics Research: Used in the design and synthesis of peptide analogs and protease inhibitors due to its pyrrolidine carboxylic acid ester structure.
• Chemical Biology Probes: Employed in the development of tool compounds and labeled ligands for target identification and validation studies.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for GMP production of advanced intermediates.
• Academic Research: A valuable reagent for methodological studies in organic synthesis and catalysis within university and institutional laboratories.

Basic Information

Product Name	Methyl (2R,3S)-3-Hydroxypyrrolidine-2-Carboxylate Hydrochloride
CAS No.	1844898-16-3
Molecular Formula	C6H12ClNO3
Molecular Weight	181.62 g/mol
Synonyms	Methyl (2R,3S)-3-hydroxypyrrolidine-2-carboxylate HCl; (2R,3S)-Methyl 3-hydroxypyrrolidine-2-carboxylate hydrochloride; L-threo-3-Hydroxypipecolic acid methyl ester hydrochloride; (2R,3S)-2-(Methoxycarbonyl)-3-hydroxypyrrolidine hydrochloride; 3-Hydroxy-D-proline methyl ester hydrochloride (stereospecific); Pyrrolidine-2-carboxylic acid, 3-hydroxy-, methyl ester, hydrochloride, (2R,3S)-; Methyl 3-hydroxy-D-prolinate hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl (2R,3S)-3-Hydroxypyrrolidine-2-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.