Description

5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester is a sophisticated bifunctional chemical building block featuring a strained bicyclic alkyne core. This compound is engineered for advanced applications in click chemistry and bioconjugation, offering a unique combination of reactivity and stability. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for the development of novel therapeutics, diagnostics, and functional polymers.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: The strained cycloalkyne moiety enables copper-free, bioorthogonal click reactions with azides for site-specific labeling of proteins, antibodies, and other biomolecules.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and production of targeted drug candidates, particularly in oncology and targeted therapy.
• Probe and Diagnostic Reagent Synthesis: Used to create fluorescent, radioactive, or affinity tags for cellular imaging, biomarker detection, and in vitro diagnostics.
• Polymer and Materials Science: Incorporated into polymer backbones or surfaces to introduce reactive handles for post-polymerization modification, creating smart or functional materials.
• Chemical Biology Tool Development: Essential for synthesizing activity-based probes and other tools to study enzyme function, metabolic pathways, and protein-protein interactions.
• Peptide and Protein Modification: Enables the stable attachment of payloads, PEG chains, or other functional groups to peptides and engineered proteins.

Basic Information

Product Name	5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester
CAS No.	1841134-72-2
Molecular Formula	C₂₁H₃₂N₂O₆
Molecular Weight	408.49 g/mol
Synonyms	(1R,8S,9S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl 13-amino-5,8,11-trioxa-2-azatridecanoate; BCN-PEG3-amine; BCN-PEG3-NH2; (1α,8α,9α)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl 13-amino-4,7,10-trioxa-13-azatridecanoate; BCN-amine-PEG3; BCN-PEG3-Amine; BCN-PEG(3)-NH2; BCN-PEG3-NH₂
EINECS	Contact for details

Quality Control

Our production of this advanced chemical intermediate adheres to strict quality management protocols. Every batch is characterized and purified to meet the high-purity demands of research and cGMP manufacturing environments. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity (by HPLC/NMR), identity confirmation, and impurity profiles to ensure batch-to-batch consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Under these conditions, the product is stable for at least 24 months. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.