Description

Azido-Peg1-Methyl Ester is a specialized bifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group and a methyl ester terminus. This compound is a crucial building block in click chemistry and bioconjugation strategies, enabling the efficient, modular assembly of complex molecular architectures. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors for applications ranging from drug delivery system development to polymer functionalization.

Application

• Bioconjugation and Linker Chemistry: Serves as a versatile heterobifunctional crosslinker for attaching molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC) click reactions.
• PEGylation Reagent: Used to introduce short PEG spacers onto drug molecules, peptides, or surfaces to improve solubility, reduce immunogenicity, and enhance pharmacokinetic properties.
• Polymer and Materials Science: Acts as a functional monomer or chain extender for synthesizing azide-functionalized polymers, hydrogels, and smart materials.
• Probe and Diagnostic Agent Synthesis: Facilitates the labeling of biomolecules (e.g., antibodies, proteins) with fluorescent dyes, affinity tags, or other reporter groups for imaging and detection.
• Chemical Biology Tool: Enables the site-specific modification of proteins and other biomacromolecules for studying structure-function relationships and cellular processes.
• Surface Modification: Used to create functionalized coatings on nanoparticles, chips, or other substrates for biosensor and microarray development.

Basic Information

Product Name	Azido-Peg1-Methyl Ester
CAS No.	1835759-80-2
Molecular Formula	C6H11N3O3
Molecular Weight	173.17 g/mol
Synonyms	2-[2-(2-Azidoethoxy)ethoxy]acetic acid methyl ester; Azido-PEG1-methyl ester; Methyl 2,5,8-trioxa-11-azadodecanoate-11-azide; 11-Azido-3,6,9-trioxaundecanoic acid methyl ester; Azido-EG1-methyl ester; Azido-triethylene glycol methyl ester; N3-PEG1-COOCH3; PEG1-azide methyl ester
EINECS	Contact for details

Quality Control

Our Azido-Peg1-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and FT-IR for functional group verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as indicated on the label or COA. Keep away from heat, sparks, open flames, and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.