Description

1,1,1-Trifluoroethyl-Peg3-Propargyl is a specialized bifunctional PEG linker featuring a trifluoroethyl group and a terminal propargyl moiety. This compound is engineered to provide a versatile platform for bioconjugation and materials science, offering enhanced stability and solubility due to its fluorinated segment and PEG spacer. It is primarily utilized by researchers and manufacturers in pharmaceutical development, advanced material synthesis, and diagnostic probe fabrication.

Application

• Bioconjugation and ADC Development: Serves as a key linker for attaching cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) research and production.
• Click Chemistry Reagent: The terminal alkyne group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling biomolecules and polymers.
• Polymer and Material Modification: Used to introduce fluorinated, hydrophilic PEG chains into polymers, surfaces, or nanoparticles to alter physicochemical properties.
• Proteomics and Biomolecule Labeling: Facilitates the site-specific tagging of proteins, peptides, and oligonucleotides for imaging, tracking, and pull-down assays.
• Diagnostic Reagent Synthesis: Acts as a building block for creating contrast agents, fluorescent probes, and other diagnostic tools.
• Solubility and Stability Enhancer: The trifluoroethyl-PEG3 chain can be incorporated into drug molecules to improve pharmacokinetic profiles.

Basic Information

Product Name	1,1,1-Trifluoroethyl-Peg3-Propargyl
CAS No.	1835759-73-3
Molecular Formula	C₁₄H₂₃F₃O₄
Molecular Weight	312.33 g/mol
Synonyms	2,2,2-Trifluoroethyl-3,6,9-trioxa-12-dodecyn-1-ol; 3,6,9-Trioxa-12-dodecyn-1-ol, 2,2,2-trifluoroethyl ether; 1,1,1-Trifluoro-2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethane; Trifluoroethyl-PEG3-propargyl ether; Propargyl-PEG3-trifluoroethyl ether; TFEE-PEG3-Alkyne; Alkyne-PEG3-TFEE
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoroethyl-Peg3-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural integrity suitable for sensitive research and development applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.