Description

Azido-PEG4-(CH2)3-methyl ester is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal azide group and a methyl ester. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient, site-specific modification of biomolecules and materials under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science who require precise and stable crosslinking for drug delivery systems, diagnostic assays, and surface functionalization.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a linker to attach cytotoxic payloads or imaging agents to antibodies, proteins, or peptides via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry (CuAAC).
• PEGylation and Protein Engineering: Facilitates the site-specific PEGylation of therapeutic proteins to enhance solubility, stability, and circulation half-life while reducing immunogenicity.
• Surface Functionalization and Material Science: Employed to modify nanoparticles, biosensors, and polymer surfaces with bioactive molecules, creating functional platforms for diagnostics and tissue engineering.
• Synthesis of Complex Biomolecular Probes: Serves as a versatile building block for constructing fluorescent probes, affinity labels, and other molecular tools for cellular imaging and target identification.
• Crosslinking Agent for Hydrogels and Biomaterials: Used in the formation of biocompatible hydrogels and scaffolds with controlled physical and chemical properties for 3D cell culture and regenerative medicine.
• Oligonucleotide and Nucleic Acid Modification: Enables the labeling and conjugation of oligonucleotides for applications in gene therapy, sequencing, and molecular diagnostics.

Basic Information

Product Name	Azido-PEG4-(CH2)3-methyl ester
CAS No.	1835759-71-1
Molecular Formula	C16H31N3O7
Molecular Weight	377.44 g/mol
Synonyms	Azido-PEG4-C3-methyl ester; 3-Azidopropyl-PEG4-methyl ester; Methyl 3-azidopropyltetraethylene glycol ester; 11-Azido-3,6,9-trioxaundecan-1-yl methyl ester; Azido-PEG4-C3-OMe; PEG4-Azide Methyl Ester; N3-PEG4-C3-COOCH3; 1-Azido-3,6,9,12-tetraoxapentadecan-15-oic acid methyl ester
EINECS	Contact for details

Quality Control

Our Azido-PEG4-(CH2)3-methyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at -20°C under desiccant. The material is moisture-sensitive; allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile, and water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.