Description

1,1,1-Trifluoroethyl-Peg2-Azide is a specialized bifunctional linker compound featuring a trifluoroethyl group and a terminal azide, connected by a polyethylene glycol (PEG) spacer. This molecular architecture is critical for enabling efficient bioconjugation and click chemistry applications, offering enhanced solubility and stability. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science, where precise molecular assembly is required.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Serves as a key linker for attaching cytotoxic payloads to monoclonal antibodies via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry.
• Proteomics and Biomarker Discovery: Used to label proteins, peptides, and other biomolecules for isolation, detection, and analysis in mass spectrometry and fluorescence imaging.
• Polymer and Materials Functionalization: Enables the surface modification of nanoparticles, hydrogels, and polymers to introduce specific biological functionalities or alter material properties.
• Chemical Biology Probe Synthesis: A versatile reagent for creating activity-based probes to study enzyme function and metabolic pathways in living systems.
• Diagnostic Reagent Formulation: Incorporated into the design of diagnostic assays and imaging agents for enhanced targeting and signal generation.
• Precision Drug Delivery Systems: Facilitates the development of targeted nanocarriers and prodrugs by providing a stable, cleavable linkage.

Basic Information

Product Name	1,1,1-Trifluoroethyl-Peg2-Azide
CAS No.	1835759-68-6
Molecular Formula	C9H14F3N3O2
Molecular Weight	253.22 g/mol
Synonyms	2,2,2-Trifluoroethyl-PEG2-azide; 1-Azido-3,6-dioxa-8-trifluoromethyloctane; 2-[2-(2-Azidoethoxy)ethoxy]-1,1,1-trifluoroethane; 8-Azido-3,6-dioxa-2,2,2-trifluoro-1-octanol; Azido-PEG2-CH2CF3; CF3CH2-PEG2-N3; Trifluoroethyl PEG2 azide; PEG2-Azide-CF3
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoroethyl-Peg2-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP-grade pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation due to its highly volatile and easily oxidized nature. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.