Description

Acid-Peg3-Pfp Ester CAS NO 1835759-67-5 is a specialized bifunctional PEG linker featuring a carboxylic acid group and a pentafluorophenyl (PFP) ester terminus. This compound is a critical reagent in bioconjugation and pharmaceutical development, enabling the efficient and selective coupling of biomolecules under mild conditions. It is primarily utilized by researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, peptide synthesis, and materials science.

Application

• Bioconjugation Reagent: For the site-specific modification of peptides, proteins, and antibodies.
• Antibody-Drug Conjugate (ADC) Linker: Serves as a key component in constructing stable, cleavable, or non-cleavable linkers for targeted cancer therapies.
• PEGylation Agent: Used to attach polyethylene glycol (PEG) chains to drugs or biomolecules to improve solubility, stability, and pharmacokinetics.
• Crosslinking and Immobilization: Facilitates the covalent attachment of biomolecules to surfaces, nanoparticles, or other polymers for diagnostic assays and biosensors.
• Solid-Phase Peptide Synthesis (SPPS): Acts as an activated ester for efficient amide bond formation during peptide chain elongation.
• Polymer and Materials Chemistry: A building block for synthesizing functionalized, water-soluble polymers and hydrogels.

Basic Information

Product Name	Acid-Peg3-Pfp Ester
CAS No.	1835759-67-5
Molecular Formula	C19H21F5O7
Molecular Weight	480.36 g/mol
Synonyms	15-Aza-3,6,9,12-tetraoxapentadecanoic acid, 15-[(2,3,4,5,6-pentafluorophenoxy)carbonyl]-; 15-[(Pentafluorophenoxy)carbonyl]-3,6,9,12-tetraoxapentadecanoic acid; Fmoc-8-amino-3,6-dioxaoctanoic acid PFP ester; PFP-PEG3-COOH; Pentafluorophenyl-PEG3-acid; Acid-PEG3-PFP ester; 4,7,10-Trioxa-13-azapentadecanoic acid, 15-oxo-15-(pentafluorophenoxy)-; PFP ester of PEG3 carboxylic acid.
EINECS	Contact for details

Quality Control

Our Acid-Peg3-Pfp Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency for sensitive research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and potentially light-sensitive nature. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.