Description

2-Chloro-3-Fluoro-4-(Methylthio)Pyridine is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique halogenated and thioether-substituted pyridine structure makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Active Ingredient Development: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the halogenated pyridine core.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as components for OLEDs or conductive polymers, due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: A valuable building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chloro-3-Fluoro-4-(Methylthio)Pyridine
CAS No.	1826110-14-8
Molecular Formula	C7H5ClFNS
Molecular Weight	189.63 g/mol
Synonyms	4-(Methylthio)-2-chloro-3-fluoropyridine; 2-Chloro-3-fluoro-4-methylsulfanylpyridine; 3-Fluoro-2-chloro-4-(methylthio)pyridine; Pyridine, 2-chloro-3-fluoro-4-(methylthio)-; 2-Chloro-3-fluoro-4-(methylmercapto)pyridine; 2-Cl-3-F-4-SMe-Pyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluoro-4-(Methylthio)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.