Description

Methyl 5-Aminobicyclo[3.1.1]heptane-1-carboxylate is a high-purity bicyclic amino ester building block of significant interest in advanced organic synthesis. This compound matters for its rigid, three-dimensional scaffold, which is highly valuable for constructing complex molecular architectures with precise stereochemistry. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and hit-to-lead optimization to explore new chemical space due to its constrained bicyclic structure.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with potentially enhanced efficacy and selectivity.
• Peptidomimetics: The bicyclic framework is utilized to create conformationally restricted peptide analogs, improving metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in catalytic asymmetric reactions to introduce stereogenic centers.
• Chemical Biology Probes: Functionalized to create tool compounds for studying enzyme function and biological pathways.

Basic Information

Product Name	Methyl 5-Aminobicyclo[3.1.1]heptane-1-carboxylate
CAS No.	1824132-78-6
Molecular Formula	C10H17NO2
Molecular Weight	183.25 g/mol
Synonyms	5-Aminobicyclo[3.1.1]heptane-1-carboxylic acid methyl ester; Methyl 5-aminonorfenchane-1-carboxylate; 1-Carbomethoxy-5-aminobicyclo[3.1.1]heptane; 5-Amino-1-(methoxycarbonyl)bicyclo[3.1.1]heptane; Bicyclo[3.1.1]heptane-1-carboxylic acid, 5-amino-, methyl ester; Aminonorfenchane carboxylate methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Aminobicyclo[3.1.1]heptane-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.