Description

tert-Butyl 6-(Methylamino)-2-azaspiro[3.3]heptane-2-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of novel drug candidates with potential applications in central nervous system (CNS) and other therapeutic areas. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small-molecule therapeutics, particularly those exploring constrained amine motifs to improve drug-like properties.

Application

• Key synthetic intermediate in the research and development of novel active pharmaceutical ingredients (APIs).
• Building block for constructing spirocyclic compounds in medicinal chemistry programs targeting neurological disorders.
• Precursor for the synthesis of potential kinase inhibitors or GPCR modulators due to its constrained, three-dimensional structure.
• Used in process chemistry for scaling up candidate molecules from discovery to preclinical and clinical stages.
• Valuable scaffold in fragment-based drug discovery (FBDD) and combinatorial chemistry libraries.
• Intermediate for producing labeled compounds (e.g., deuterated or carbon-14 labeled) for pharmacokinetic and metabolic studies.

Basic Information

Item	Details
Product Name	tert-Butyl 6-(Methylamino)-2-azaspiro[3.3]heptane-2-carboxylate
CAS No.	1824024-00-1
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-(methylamino)-, 1,1-dimethylethyl ester; 6-(Methylamino)-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; tert-Butyl 6-(methylamino)-2-azaspiro[3.3]heptane-2-carboxylate; 2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-(methylamino)-, tert-butyl ester; 1824024-00-1; 6-(Methylamino)-2-azaspiro[3.3]heptane-2-carboxylic acid, tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(Methylamino)-2-azaspiro[3.3]heptane-2-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our commitment to quality assurance supports your R&D and scale-up processes with reliable, high-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C (refrigerated) or as indicated on the specific product label.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.