Description

6-Azaspiro[3.4]Octan-1-Ol Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic amine structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of complex molecules targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained spirocyclic scaffold.
• Proteolysis Targeting Chimera (PROTAC) Synthesis: Serves as a component in the linker or warhead sections of bifunctional degrader molecules.
• Chemical Biology Research: Employed as a tool compound or a precursor for probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules under cGMP conditions.

Basic Information

Product Name	6-Azaspiro[3.4]Octan-1-Ol Hydrochloride
CAS No.	1823886-51-6
Molecular Formula	C7H14ClNO
Molecular Weight	163.65 g/mol
Synonyms	1-Hydroxy-6-azaspiro[3.4]octane hydrochloride; 6-Azaspiro[3.4]octan-1-ol, hydrochloride; 1-Hydroxy-6-azaspiro[3.4]octane HCl; 6-Azaspiro[3.4]octan-1-ol HCl; 1823886-51-6; Spirocyclic amine hydrochloride; Azaspirooctanol hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Azaspiro[3.4]Octan-1-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a desiccator for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.